Curriculum

The complete syllabus

281 lessons in 12 modules, taught in sequence but open in any order. Nine modules follow the practitioner curriculum; two more, drawn from the MultiOmix book, turn the toolkit into whole-patient practice.

Developed by Epivity Longevity Clinic in Norway in collaboration with the Norwegian health authorities, and offered in the United Arab Emirates by MultiOmix.

Guided study: 16 hours
Deep dives: 216
Figures & tables: 329
Assessment items: 250

Module 01 · Practitioner curriculum

Foundations of Longevity Medicine

This module establishes the conceptual and clinical foundation for the entire course. It defines what longevity medicine is (and is not), introduces the biology of aging and its clinical hallmarks, and builds the assessment and risk-stratification framework used throughout every subsequent module. Content is drawn from peer-reviewed literature and leading academic centers - Harvard Medical School, Harvard T.H. Chan School of Public Health, Stanford Center on Longevity, Stanford Medicine - together with prominent clinical and public voices in the field, including David Sinclair, PhD (Harvard Medical School), Peter Attia, MD, and consumer-facing longevity programs such as Bryan Johnson's Blueprint and Levels, which are examined critically as case studies rather than as clinical standards.

Lessons

1 h 14 min

Study time

View all 19 lessons and 5 knowledge checks

9 learning objectives · 10 key takeaways · 24 references

Open module

Module 02 · Practitioner curriculum

Biomarkers & Comprehensive Health Assessment

Part 2 is the largest module in the course because it builds the single most-used clinical skill in longevity medicine: reading a comprehensive panel accurately. It covers what makes a biomarker clinically useful, how to read reference ranges critically, and a systematic walk-through of every major panel category - hematology, iron, renal, hepatic, lipid and advanced lipid, glycemic, inflammatory, thyroid, hormonal, micronutrient, homocysteine, and oxidative-stress markers - before moving into body composition, vascular, and functional assessment, and finally into the integration skills that turn 150+ data points into a small number of prioritized clinical actions. As in Part 1, sourcing is drawn from Harvard, Stanford, and peer-reviewed literature, together with the frameworks used by Peter Attia, David Sinclair, and consumer programs such as Bryan Johnson's Blueprint and Levels - again examined critically rather than adopted as clinical standard.

Lessons

1 h 31 min

Study time

View all 33 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 24 references

Open module

Module 03 · Practitioner curriculum

Cardiovascular Longevity

Cardiovascular disease is the leading cause of death worldwide, and it is also the domain of longevity medicine with the deepest and most rigorous evidence base of any pillar in this course. Part 3 builds a complete, evidence-graded approach to cardiovascular risk: the biology of the risk continuum, traditional and advanced risk markers (ApoB, Lp(a), coronary artery calcium), the major modifiable drivers (metabolic, inflammatory, behavioral), and the lifestyle and pharmacological interventions with genuine randomized-trial support behind them. Sourcing draws on landmark outcome trials (CTT, REDUCE-IT, FOURIER, CANTOS, LoDoCo2, PREDIMED), AHA/ACC/ESC guidelines, Harvard and Stanford research, and the frameworks used by Peter Attia and David Sinclair - with commercial programs such as Bryan Johnson's Blueprint and Levels again treated as case studies, not clinical standards.

Lessons

1 h 34 min

Study time

View all 29 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 34 references

Open module

Module 04 · Practitioner curriculum

Metabolic Health & Insulin Resistance

Metabolic dysfunction - led by insulin resistance - is arguably the single most common upstream driver of chronic disease covered anywhere in this course: it accelerates cardiovascular risk (Part 3), drives fatty liver disease, and sits behind a large share of the hallmarks of aging introduced in Part 1. Part 4 builds a complete, mechanistic understanding of metabolic health, from glucose homeostasis and insulin resistance biology through the full progression from prediabetes to type 2 diabetes, and closes with the strongest available evidence on reversal - including two landmark trials, the Diabetes Prevention Program and DiRECT, that show metabolic dysfunction is often preventable and, in a meaningful subset of patients, reversible. As in prior modules, sourcing draws on Harvard, Stanford, landmark randomized trials, and the frameworks used by Peter Attia and David Sinclair, with commercial programs such as Bryan Johnson's Blueprint and Levels treated as case studies rather than clinical standards.

Lessons

1 h 18 min

Study time

View all 26 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 22 references

Open module

Module 05 · Practitioner curriculum

Biological Age & Epigenetics

self-checks Part 5 goes beneath the biomarkers of Parts 2-4 to the molecular layer that helps explain why two patients of the same chronological age can have very different disease risk and physiological resilience - biological aging, measured through epigenetics. Building on the chronological-versus-biological-age distinction introduced in Part 1 (Section 1.9) and the one-carbon methylation biochemistry from Part 2 (Section 2.17), this module covers how DNA methylation changes across the lifespan, how epigenetic “clocks” translate that into an age estimate, what three successive generations of clocks were each built to predict, and - critically - what these tests can and cannot responsibly tell a physician today. As with Bryan Johnson's Blueprint and Levels in earlier parts, commercial epigenetic testing platforms such as TruDiagnostic are treated here as case studies in an emerging field, not as established clinical standards.

Lessons

1 h 22 min

Study time

View all 25 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 24 references

Open module

Module 06 · Practitioner curriculum

Genetics & Advanced Testing

self-checks Part 6 is the widest-lens module in the course. It starts with genetics proper - single variants, family history, and polygenic risk scores - moves through the specific genetic contributors to cardiovascular, metabolic, cancer, and drug-response risk, and then surveys the fast-growing field of advanced testing beyond genetics: telomeres, advanced lipid and metabolic panels, proteomics, metabolomics, and the microbiome. The throughline, consistent with every prior part, is disciplined evidence evaluation: some of this content (pharmacogenomics for specific drug-gene pairs, hereditary cancer syndromes) is genuinely practice-changing and underused; a meaningful share of what is marketed directly to consumers (unvalidated nutrigenomic panels, unproven microbiome-based dietary prescriptions) remains Tier 3-4 evidence dressed in Tier 1 language. Sourcing draws on CPIC, NCCN, ACMG, ESC, and ACC/AHA guidelines alongside the course's standing high-authority sources - Harvard, Stanford, Peter Attia, and David Sinclair - with commercial genetic and multi-omics platforms treated, as in prior parts, as case studies rather than clinical standards.

Lessons

1 h 18 min

Study time

View all 27 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 22 references

Open module

Module 07 · Practitioner curriculum

Exercise, Fitness & Physical Performance

self-checks Exercise is, by a wide margin, the single most-studied and most effective intervention covered anywhere in this course - and Part 7 is where its evidence base gets the depth it deserves. Cardiorespiratory fitness (Part 3, Section 3.19), muscular strength, and exercise's downstream effects on metabolic (Part 4, Section 4.19), cardiovascular (Part 3, Section 3.20), and biological-aging (Part 5, Section 5.16) outcomes have each been introduced already; this module builds the complete physiological and practical picture, from VO2max testing and heart rate variability through resistance training, zone-based and high-intensity prescription, recovery science, and how to translate all of it into a sustainable, individualized longevity exercise plan. As throughout this course, wearable fitness technology is treated with the same evidence discipline applied to Bryan Johnson's Blueprint and Levels in earlier parts - a genuinely useful but imperfect tool, not an infallible oracle.

Lessons

1 h 25 min

Study time

View all 27 lessons and 6 knowledge checks

8 learning objectives · 10 key takeaways · 19 references

Open module

Module 08 · Practitioner curriculum

Nutrition, Sleep & Recovery

evidence · self-checks Nutrition, sleep, and recovery are the three daily-repeated inputs that shape almost every biomarker and outcome covered elsewhere in this course - cardiovascular risk (Part 3), metabolic health (Part 4), biological aging (Part 5), and physical performance (Part 7) all sit downstream of what a patient eats, how well they sleep, and whether their body gets a genuine chance to recover. Earlier parts introduced nutrition and sleep as risk-modifying factors within a specific organ system; this module is where they get the depth of treatment they deserve as clinical disciplines in their own right - macronutrient physiology, dietary-pattern evidence, fasting and meal timing, alcohol's revised risk profile, sleep architecture and disorders, circadian biology, the physiology of stress and recovery, and how to translate all of it into a single, individualized, sustainable plan. As throughout this course, commercial supplement and wellness-tracking claims are held to the same evidence bar as Bryan Johnson's Blueprint and Levels protocols discussed in earlier parts - useful signal exists, but it must be separated carefully from marketing.

Lessons

1 h 30 min

Study time

View all 27 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 26 references

Open module

Module 09 · Practitioner curriculum

Longevity Interventions & Protocols

evidence · self-checks Parts 1 through 8 built the complete diagnostic and physiological foundation of longevity medicine - biomarkers, cardiovascular and metabolic risk, biological aging, genetics, exercise physiology, and nutrition and sleep science. Part 9 is where all of that assessment work becomes action. This module covers how to translate findings into a structured, individualized, evidence-graded protocol: the foundational role of lifestyle and behavior change, how to layer targeted clinical interventions (hormonal optimization, evidence-based supplementation) and pharmacological options on top of that foundation, how to evaluate emerging and experimental therapies without overstating their evidence, and how to build the ongoing cycle of monitoring and adjustment that separates a real longevity practice from a one-time consultation. As throughout this course, every intervention category here - including hormone therapy, peptides, and IV protocols, all heavily marketed in the commercial longevity space that Bryan Johnson's Blueprint and Levels represent - is held to the same evidence-tiering discipline established in Part 1, Section 1.12, with clear distinctions drawn between established clinical practice and genuinely experimental care.

Lessons

1 h 30 min

Study time

View all 27 lessons and 5 knowledge checks

8 learning objectives · 10 key takeaways · 21 references

Open module

Module 10 · Practitioner curriculum

Functional Medicine: Principles and Clinical Practice

This module trains a practising physician to deliver functional medicine competently and credibly: to find why a patient became unwell, map the interacting causes, choose tests with discipline, and build a personalised, evidence-graded plan that integrates with conventional care. Ten lessons, each with a knowledge check, a four-case library with model answers, and a twenty-question module assessment.

Lessons

1 h 47 min

Study time

View all 14 lessons and 11 knowledge checks

9 learning objectives · 10 key takeaways · 18 references

Open module

Module 11 · From the MultiOmix book

Longevity Across the Lifespan & Integrated Case Studies

Parts 1-9 built the toolkit one system at a time. This module puts it to work on whole patients. The first half walks decade by decade through what a longevity plan should prioritise - from the baseline that only the twenties can provide to the functional independence that becomes the real outcome after seventy. The second half is a case conference: four patients followed across the course return with their complete protocols, showing depth, a single reorganising finding, sequencing, and restraint as four different shapes of the same seven-step process.

Lessons

39 min

Study time

View all 13 lessons and 2 knowledge checks

7 learning objectives · 9 key takeaways

Open module

Module 12 · From the MultiOmix book

Critical Appraisal, the Longevity Industry & the Next Decade

Patients arrive with protocols they have already paid for and headlines they have already read. This final module equips the physician to answer both. It builds a working evidence hierarchy, a ten-point red-flag checklist and a six-question method for reading any study, then applies them to the claims most often met in practice - consumer biological-age kits, exosome and stem-cell infusions, NAD+ subscriptions, unregulated peptides and wearable 'longevity scores'. It closes with an honest account of the research pipeline as of 2026 - partial reprogramming, senolytics, the TAME trial and AI-accelerated discovery - and a ninety-day plan for turning the course into practice.

Lessons

52 min

Study time

View all 14 lessons and 3 knowledge checks

8 learning objectives · 11 key takeaways

Open module

Assessment & certification

How completion is assessed

Formative checks

250 single-best-answer questions placed through the modules, each with an explained rationale. Retake freely; your best score is kept.

Final assessment

50 questions sampled in proportion from all twelve modules, with a 60-minute guide time. The pass mark is 80%.

Live workshop

After the digital modules, a one-day live workshop where you apply the course to real patient cases with the faculty.

Certificate

Issued after you have completed both the digital modules and the workshop, carrying your name, the date and the curriculum covered.

Go to the final assessment